YB-1 is important for late-stage embryonic development, optimal cellular stress responses, and the prevention of premature senescence.

@article{Lu2005YB1II,
  title={YB-1 is important for late-stage embryonic development, optimal cellular stress responses, and the prevention of premature senescence.},
  author={Zhi Hong Lu and Jason T Books and Timothy J. Ley},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 11},
  pages={4625-37}
}
Proteins containing "cold shock" domains belong to the most evolutionarily conserved family of nucleic acid-binding proteins known among bacteria, plants, and animals. One of these proteins, YB-1, is widely expressed throughout development and has been implicated as a cell survival factor that regulates the transcription and/or translation of many cellular growth and death-related genes. For these reasons, YB-1 deficiency has been predicted to be incompatible with cell survival. However, the… CONTINUE READING