YB-1 and CTCF differentially regulate the 5-HTT polymorphic intron 2 enhancer which predisposes to a variety of neurological disorders.

@article{Klenova2004YB1AC,
  title={YB-1 and CTCF differentially regulate the 5-HTT polymorphic intron 2 enhancer which predisposes to a variety of neurological disorders.},
  author={Elena M. Klenova and A. Carlisle Scott and Julian C Roberts and Shaharum Shamsuddin and Elizabeth A. Lovejoy and Stephan Bergmann and Vivien Jill Bubb and Harriette Royer and J P Quinn},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2004},
  volume={24 26},
  pages={
          5966-73
        }
}
The serotonin transporter (5-HTT) gene contains a variable number tandem repeat (VNTR) domain within intron 2 that is often associated with a number of neurological conditions, including affective disorders. The implications of this polymorphism are not yet understood, however, we have previously demonstrated that the 5-HTT VNTR is a transcriptional regulatory domain, and the allelic variation supports differential reporter gene expression in vivo and in vitro. The aim of this study was to… CONTINUE READING

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