YAP1-TEAD1 signaling controls angiogenesis and mitochondrial biogenesis through PGC1α.

Abstract

Mitochondria contribute to key processes of cellular function, while mitochondrial dysfunction is implicated in metabolic disorders, neurodegenerative diseases, and cardiovascular diseases, in which angiogenesis - the formation of new blood capillaries - is dysregulated. The Hippo signaling transducer, Yes-associated protein (YAP1) binds to the TEA domain… (More)
DOI: 10.1016/j.mvr.2018.04.003

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