YAP regulates cell mechanics by controlling focal adhesion assembly

Abstract

Hippo effectors YAP/TAZ act as on-off mechanosensing switches by sensing modifications in extracellular matrix (ECM) composition and mechanics. The regulation of their activity has been described by a hierarchical model in which elements of Hippo pathway are under the control of focal adhesions (FAs). Here we unveil the molecular mechanism by which cell… (More)
DOI: 10.1038/ncomms15321

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