YAP enhances the pro-proliferative transcriptional activity of mutant p53 proteins.


Mutant p53 proteins are present in more than half of human cancers. Yes-associated protein (YAP) is a key transcriptional regulator controlling organ growth, tissue homeostasis, and cancer. Here, we report that these two determinants of human malignancy share common transcriptional signatures. YAP physically interacts with mutant p53 proteins in breast… (More)
DOI: 10.15252/embr.201540488


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