YAC transgenic mice carrying pathological alleles of the MJD1 locus exhibit a mild and slowly progressive cerebellar deficit.

@article{Cemal2002YACTM,
  title={YAC transgenic mice carrying pathological alleles of the MJD1 locus exhibit a mild and slowly progressive cerebellar deficit.},
  author={Cemal K Cemal and Christopher James Carroll and Lorraine Lawrence and Margaret B. Lowrie and Piers Ruddle and Sahar Al-Mahdawi and Rosalind H. M. King and Mark Pook and Clare Huxley and Susan Chamberlain},
  journal={Human molecular genetics},
  year={2002},
  volume={11 9},
  pages={
          1075-94
        }
}
Machado-Joseph disease (MJD; MIM 109150) is a late-onset neurodegenerative disorder caused by the expansion of a polyglutamine tract within the MJD1 gene. We have previously reported the generation of human yeast artificial chromosome (YAC) constructs encompassing the MJD1 locus into which expanded (CAG)(76) and (CAG)(84) repeat motifs have been introduced by homologous recombination. Transgenic mice containing pathological alleles with polyglutamine tract lengths of 64, 67, 72, 76 and 84… CONTINUE READING

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