Y-family DNA polymerases in mammalian cells

@article{Guo2009YfamilyDP,
  title={Y-family DNA polymerases in mammalian cells},
  author={Caixia Guo and J. Nicole Kosarek-Stancel and Tie-Shan Tang and Errol C. Friedberg},
  journal={Cellular and Molecular Life Sciences},
  year={2009},
  volume={66},
  pages={2363-2381}
}
Eukaryotic genomes are replicated with high fidelity to assure the faithful transmission of genetic information from one generation to the next. The accuracy of replication relies heavily on the ability of replicative DNA polymerases to efficiently select correct nucleotides for the polymerization reaction and, using their intrinsic exonuclease activities, to excise mistakenly incorporated nucleotides. Cells also possess a variety of specialized DNA polymerases that, by a process called… 

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TLDR
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TLDR
Using NMR spectroscopy, the structure of a complex of human Polι UBM2 and Ubiquitin is determined, revealing a novel ubiquitin recognition fold consisting of two α-helices separated by a central trans-proline residue conserved in all UBMs.

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