Y chromosome haplotypes and prostate cancer in Sweden.

Abstract

PURPOSE Certain Y-chromosomal lineages have been suggested to predispose individuals to prostate cancer in the Japanese population; in other ethnic groups, however, the importance of the Y chromosome is poorly understood. EXPERIMENTAL DESIGN To assess the possible Y-chromosomal contribution to prostate cancer risk and prognosis, we analyzed five binary Y-chromosomal markers in 1,447 prostate cancer cases and 983 population controls from the Swedish population. Together, these five markers capture the vast majority of chromosome Y haplogroup diversity in the Swedish population. Individual lineages were tested for association with both prostate cancer risk and cancer-specific death. We replicated observed associations in an independent Swedish prostate cancer case-control study comprising 1,452 cases and 779 controls. RESULTS One rare lineage (I1c) was associated with an increased risk of developing prostate cancer [odds ratio (OR), 2.9; 95% confidence interval (CI), 1.4-5.8; P = 0.001]. However, confirmatory analysis of this lineage in the independent case-control study revealed no association with prostate cancer risk (OR, 0.65; 95% CI, 0.4-1.2, P = 0.17). We observed no association between chromosome Y variation and prostate cancer-specific death. CONCLUSIONS This study provides strong evidence against an important role of the Y chromosome in the initiation or outcome of prostate cancer in the Swedish population.

DOI: 10.1158/1078-0432.CCR-08-0658

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@article{Lindstrm2008YCH, title={Y chromosome haplotypes and prostate cancer in Sweden.}, author={Sara Lindstr{\"{o}m and Hans-olov Adami and Jan Adolfsson and Fredrik Wiklund}, journal={Clinical cancer research : an official journal of the American Association for Cancer Research}, year={2008}, volume={14 20}, pages={6712-6} }