Y chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry

@inproceedings{Wang2012YCH,
  title={Y chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry},
  author={Zhaoming Wang and Hemang Parikh and Jinping Jia and Timothy A Myers and Meredith Yeager and Kevin B. Jacobs and Amy A. Hutchinson and Laurie A. Burdett and Arpita Ghosh and Michael J. Thun and Susan M. Gapstur and W. Ryan Diver and Jarmo R Virtamo and Demetrius Albanes and G{\'e}raldine Cancel-Tassin and Antoine Val{\'e}ri and Olivier Cussenot and Kenneth Offit and Ed L Giovannucci and Jing Ma and Meir Jonathan Stampfer and J. Michael Gaziano and David J. Hunter and Ana Virginia Dutra-Clarke and Tomas Kirchhoff and Michael C. R. Alavanja and Laura E. Beane Freeman and Stella Koutros and Robert Nathaniel Hoover and Sonja I. Berndt and Richard B Hayes and Ilir Agalliu and Robert D Burk and Sholom Wacholder and Gilles Thomas and Laufey T Amundadottir},
  booktitle={Human Genetics},
  year={2012}
}
Genetic variation on the Y chromosome has not been convincingly implicated in prostate cancer risk. To comprehensively analyze the role of inherited Y chromosome variation in prostate cancer risk in individuals of European ancestry, we genotyped 34 binary Y chromosome markers in 3,995 prostate cancer cases and 3,815 control subjects drawn from four studies. In this set, we identified nominally significant association between a rare haplogroup, E1b1b1c, and prostate cancer in stage I (P = 0.012… CONTINUE READING