Y chromosome evidence for a founder effect in Ashkenazi Jews

@article{Nebel2005YCE,
  title={Y chromosome evidence for a founder effect in Ashkenazi Jews},
  author={Almut Nebel and Dvora Filon and Marina Faerman and Himla Soodyall and Ariella Oppenheim},
  journal={European Journal of Human Genetics},
  year={2005},
  volume={13},
  pages={388-391}
}
Recent genetic studies, based on Y chromosome polymorphic markers, showed that Ashkenazi Jews are more closely related to other Jewish and Middle Eastern groups than to their host populations in Europe. However, Ashkenazim have an elevated frequency of R-M17, the dominant Y chromosome haplogroup in Eastern Europeans, suggesting possible gene flow. In the present study of 495 Y chromosomes of Ashkenazim, 57 (11.5%) were found to belong to R-M17. Detailed analyses of haplotype structure… Expand
Population Genetics of the Ashkenazim
TLDR
Ashkenazi Jews appear as a relatively homogenous population which has retained its identity despite nearly 2000 years of isolation and is closely related to other Jewish communities tracing their common origin to the Middle East. Expand
Phylogenetic applications of whole Y-chromosome sequences and the Near Eastern origin of Ashkenazi Levites
TLDR
The analysis of 16 whole R1 sequences shows that a set of 19 unique nucleotide substitutions defines the Ashkenazi R1a lineage, indicative of a geographic source of the Levite founder lineage in the Near East and its likely presence among pre-Diaspora Hebrews. Expand
The origin of Eastern European Jews revealed by autosomal, sex chromosomal and mtDNA polymorphisms
TLDR
The close genetic resemblance to Italians accords with the historical presumption that Ashkenazi Jews started their migrations across Europe in Italy and with historical evidence that conversion to Judaism was common in ancient Rome. Expand
Haplotype analysis of α-thalassemia chromosomes reveals heterogeneity and multiple founders in Ashkenazi Jews.
TLDR
High frequency of the common Ia haplotype in Yemenite Jews and Arabs and a high frequency of IIIb alleles previously reported only in Aboriginal Australians and not found in other Israeli ethnicities may suggest multiple founder effects in Ashkenazi Jews as well a common founder for both Yemenite and Ashkenazim. Expand
Analysis of genetic variation in Ashkenazi Jews by high density SNP genotyping
TLDR
Any putative advantage in whole genome association mapping using the AJ population will be highly dependent on regional LD structure, andLD in the AJ versus was lower than expected by some measures and higher by others. Expand
The genetic variation in the R1a clade among the Ashkenazi Levites’ Y chromosome
Approximately 300,000 men around the globe self-identify as Ashkenazi Levites, of whom two thirds were previously shown to descend from a single male. The paucity of whole Y-chromosome sequencesExpand
Abraham's children in the genome era: major Jewish diaspora populations comprise distinct genetic clusters with shared Middle Eastern Ancestry.
TLDR
This study demonstrates that European/Syrian and Middle Eastern Jews represent a series of geographical isolates or clusters woven together by shared IBD genetic threads. Expand
The population genetics of the Jewish people
TLDR
The population genetic architecture of Jews helps to explain the observed patterns of health and disease-relevant mutations and phenotypes which continue to be carefully studied and catalogued, and represent an important resource for human medical genetics research. Expand
Phylogeographic analysis of paternal lineages in NE Portuguese Jewish communities.
TLDR
The genetic composition of the Portuguese Jewish communities from Trás-os-Montes is examined, with a high-resolution Y-chromosome typing strategy, to clarify how these communities avoided the expected inbreeding caused by over four centuries of religious repression. Expand
A MOSAIC OF PEOPLE: THE JEWISH STORY AND A REASSESSMENT OF THE DNA EVIDENCE
The focus of the present study is to analyze and reassess Ashkenazi results obtained by DNA researchers and synthesize them into a coherent picture of Jewish genetics, interweaving historicalExpand
...
1
2
3
...

References

SHOWING 1-10 OF 22 REFERENCES
Multiple origins of Ashkenazi Levites: Y chromosome evidence for both Near Eastern and European ancestries.
TLDR
Comparisons with other Jewish and non-Jewish groups suggest that a founding event, probably involving one or very few European men occurring at a time close to the initial formation and settlement of the Ashkenazi community, is the most likely explanation for the presence of this distinctive haplogroup found today in >50% ofAshkenazi Levites. Expand
Jewish and Middle Eastern non-Jewish populations share a common pool of Y-chromosome biallelic haplotypes.
TLDR
The hypothesis that the paternal gene pools of Jewish communities from Europe, North Africa, and the Middle East descended from a common Middle Eastern ancestral population is supported, and most Jewish communities have remained relatively isolated from neighboring non-Jewish communities during and after the Diaspora is suggested. Expand
The common, Near‐Eastern origin of Ashkenazi and Sephardi Jews supported by Y‐chromosome similarity
TLDR
A preliminary evaluation suggests that the contribution of foreign males to the Ashkenazi gene pool has been very low (1% or less per generation). Expand
The Y chromosome pool of Jews as part of the genetic landscape of the Middle East.
TLDR
The investigation of the genetic relationship among three Jewish communities revealed that Kurdish and Sephardic Jews were indistinguishable from one another, whereas both differed slightly, yet significantly, from Ashkenazi Jews. Expand
Armenian Y chromosome haplotypes reveal strong regional structure within a single ethno-national group
TLDR
The haplotype distribution and pattern of genetic distances suggest a high degree of genetic isolation in the mountainous southern and eastern regions, while in the northern, central and western regions there has been greater admixture with populations from neighbouring Middle Eastern countries. Expand
The Eurasian Heartland: A continental perspective on Y-chromosome diversity
TLDR
This study reports the frequencies of 23 Y-chromosome biallelic polymorphism haplotypes in 1,935 men from 49 Eurasian populations, with a particular focus on Central Asia. Expand
A genetic landscape reshaped by recent events: Y-chromosomal insights into central Asia.
TLDR
Two particularly striking features were seen: an extremely high level of Y-chromosomal differentiation between geographically close populations, accompanied by low diversity within some populations, and the occurrence of several recent bottlenecks or founder events. Expand
Dual origins of Finns revealed by Y chromosome haplotype variation.
TLDR
Genetic evidence for the dual origins of Finns is presented by evaluating the pattern of Y chromosome variation in 280 unrelated males from nine Finnish provinces and revealing two major star-shaped clusters of Y haplotypes, indicative of a population expansion from two common Y chromosomes. Expand
The 49a,f haplotype 11 is a new marker of the EU19 lineage that traces migrations from northern regions of the Black Sea.
TLDR
This study surveyed 2,235 individuals from Europe and the Middle East for the 49a,f Ht11 and for many biallelic markers defining the Eu19 lineage, suggesting the influence of the Ukraine Palaeolithic groups in the gene pool of modern populations. Expand
Testing hypotheses of language replacement in the Caucasus: evidence from the Y-chromosome
TLDR
Whereas the mtDNA results show that Caucasian groups are more closely related genetically to European than to Near Eastern groups, by contrast the Y-chromosome shows a closer genetic relationship with the Near East than with Europe. Expand
...
1
2
3
...