Y-chromosome deletions in idiopathic severe testiculopathies.

  title={Y-chromosome deletions in idiopathic severe testiculopathies.},
  author={C Foresta and Alberto Ferlin and Andrea Garolla and Marco Rossato and Sandrine Barbaux and Alessandro De Bortoli},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={82 4},
A genetic etiology has been recently proposed for some severe forms of idiopathic male infertility and a region of the Y chromosome long arm (Yq) defined AZF is thought to be critical for the regulation of spermatogenesis. To date, two genes, YRRM and DAZ, have been identified in AZF, but the actual relationship between genotype and phenotype related to AZF deletions is not well characterized. By means of a PCR strategy we typed Yq microdeletions in 16 azoospermic and 22 severely… CONTINUE READING
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