Y-box protein 1 stimulates mesangial cell proliferation via activation of ERK1/2.

@article{Feng2009YboxP1,
  title={Y-box protein 1 stimulates mesangial cell proliferation via activation of ERK1/2.},
  author={Quancheng Feng and Song-ming Huang and Aihua Zhang and Qiuxia Chen and Xi-rong Guo and Ronghua Chen and Tianxin Yang},
  journal={Nephron. Experimental nephrology},
  year={2009},
  volume={113 1},
  pages={e16-25}
}
AIMS To investigate the effects of Y-box protein 1 (YB-1) on the mitogen-activated protein kinase pathway to ascertain which signaling pathway is involved in YB-1-induced mesangial cell (MC) proliferation. METHODS The rat MC line HBZY-1 was transfected with pcDNA3.1-YB-1. Cell proliferation was determined by [(3)H]thymidine incorporation, cell counting and cell-cycle analysis. The expression of cyclins was examined by real-time RT-PCR and immunoblotting analysis. Phosphorylation of c-Raf… CONTINUE READING