Y-box-binding protein YB-1 mediates transcriptional repression of human alpha 2(I) collagen gene expression by interferon-gamma.

@article{Higashi2003YboxbindingPY,
  title={Y-box-binding protein YB-1 mediates transcriptional repression of human alpha 2(I) collagen gene expression by interferon-gamma.},
  author={Kiyoshi Higashi and Yutaka Inagaki and Noriyuki Suzuki and Shinichi Mitsui and Alain Mauviel and Hideo Kaneko and Iwao Nakatsuka},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 7},
  pages={5156-62}
}
We have demonstrated previously that a proximal element within the human alpha2(I) collagen gene (COL1A2) promoter mediates transcriptional repression by interferon-gamma (IFN-gamma), and designated this region the IFN-gamma response element (IgRE). Screening of a human fibroblast cDNA expression library with a radiolabeled IgRE probe exclusively yielded clones with a sequence identical to that of the transcription factor YB-1. Electrophoretic mobility shift assays (EMSA) using various IgRE… CONTINUE READING

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