Y-box-binding protein 1 confers EGF independence to human mammary epithelial cells

@article{Berquin2005YboxbindingP1,
  title={Y-box-binding protein 1 confers EGF independence to human mammary epithelial cells},
  author={Isabelle M. Berquin and Bing Pang Pang and Michele L. Dziubinski and Latanya M Scott and Yong Q. Chen and Garry P. Nolan and Stephen P Ethier},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={3177-3186}
}
The epidermal growth factor receptor (EGFR) is linked to poor outcome in breast cancer, and resistance to hormonal therapy is often accompanied by activation of growth factor receptors. To investigate the mechanism(s) by which EGFR becomes activated in breast cancer, we screened a cDNA expression library for genes that mediate EGF-independent proliferation of human mammary epithelial cells (HMECs). We isolated the NSEP1 cDNA encoding Y-box-binding protein 1 (YB-1), a multifunctional… CONTINUE READING

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