Xylosyltransferase-I Regulates Glycosaminoglycan Synthesis during the Pathogenic Process of Human Osteoarthritis

Abstract

Loss of glycosaminoglycan (GAG) chains of proteoglycans (PGs) is an early event of osteoarthritis (OA) resulting in cartilage degradation that has been previously demonstrated in both huma and experimental OA models. However, the mechanism of GAG loss and the role of xylosyltransferase-I (XT-I) that initiates GAG biosynthesis onto PG molecules in the… (More)
DOI: 10.1371/journal.pone.0034020

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@inproceedings{Venkatesan2012XylosyltransferaseIRG, title={Xylosyltransferase-I Regulates Glycosaminoglycan Synthesis during the Pathogenic Process of Human Osteoarthritis}, author={N. E. Venkatesan and Lydia Barr{\'e} and Mustapha Bourhim and Jacques Magdalou and Didier Mainard and Patrick Netter and Sylvie Fournel-Gigleux and Mohamed Ouzzine}, booktitle={PloS one}, year={2012} }