Xylopyranoside-based agonists of D-myo-inositol 1,4,5-trisphosphate receptors: synthesis and effect of stereochemistry on biological activity.

@article{Rosenberg2001XylopyranosidebasedAO,
  title={Xylopyranoside-based agonists of D-myo-inositol 1,4,5-trisphosphate receptors: synthesis and effect of stereochemistry on biological activity.},
  author={H. Rosenberg and A. Riley and R. D. Marwood and V. Corr{\^e}a and C. Taylor and Potter BVL},
  journal={Carbohydrate research},
  year={2001},
  volume={332 1},
  pages={
          53-66
        }
}
  • H. Rosenberg, A. Riley, +3 authors Potter BVL
  • Published 2001
  • Chemistry, Medicine
  • Carbohydrate research
  • The synthesis of a series of tetrahydrofuranyl alpha- and beta-xylopyranoside trisphosphates, designed by excision of three motifs of adenophostin A is reported. The synthetic route features improved preparations of allyl alpha-D-xylopyranoside and its 2-O-benzyl ether, and gives access to four diastereoisomeric trisphosphates, which show a range of abilities to mobilise Ca2+ from the intracellular stores of hepatocytes. A comparison of the potencies of the four trisphosphates provides useful… CONTINUE READING
    14 Citations
    Structural determinants of adenophostin A activity at inositol trisphosphate receptors.
    • 45
    • PDF
    Interaction of the Catalytic Domain of Inositol 1,4,5‐Trisphosphate 3‐Kinase A with Inositol Phosphate Analogues
    • 9

    References

    SHOWING 1-10 OF 25 REFERENCES
    C-glycoside based mimics of D-myo-inositol 1,4,5-trisphosphate.
    • 13
    Inframolecular studies of the protonation of adenophostin A: comparison with 1-D-myo-inositol 1,4,5-trisphosphate.
    • 15