Xyloketal B exerts antihypertensive effect in renovascular hypertensive rats via the NO-sGC-cGMP pathway and calcium signaling

@article{Zhao2018XyloketalBE,
  title={Xyloketal B exerts antihypertensive effect in renovascular hypertensive rats via the NO-sGC-cGMP pathway and calcium signaling},
  author={Li-yan Zhao and Jie Li and Xiong-qing Huang and Guo-hao Wang and Xiaofei Lv and Wei-feng Meng and Wansheng Chen and Ji-yan Pang and Yong-cheng Lin and Hong-Shuo Sun and Guan-lei Wang and Yao-min Du},
  journal={Acta Pharmacologica Sinica},
  year={2018},
  volume={39},
  pages={875-884}
}
Xyloketal B (Xyl-B) is a novel marine compound isolated from mangrove fungus Xylaria sp. (No 2508). We previously showed that Xyl-B promoted endothelial NO release and protected against atherosclerosis through the Akt/eNOS pathway. Vascular NO production regulates vasoconstriction in central and peripheral arteries and plays an important role in blood pressure control. In this study, we examined whether Xyl-B exerted an antihypertensive effect in a hypertensive rat model, and further explored… CONTINUE READING
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