Xylodon flaviporus-Derived Drimane Sesquiterpenoids That Inhibit Osteoclast Differentiation.

  title={Xylodon flaviporus-Derived Drimane Sesquiterpenoids That Inhibit Osteoclast Differentiation.},
  author={Jaeyoung Kwon and Hyaemin Lee and S. M. Ryu and Y. Jang and Hak Cheol Kwon and Yuanqiang Guo and J. Kang and Jae-Jin Kim and Dongho Lee},
  journal={Journal of natural products},
  • Jaeyoung Kwon, Hyaemin Lee, +6 authors Dongho Lee
  • Published 2019
  • Chemistry, Medicine
  • Journal of natural products
  • The presence of excessive osteoclasts is a major factor in skeletal diseases. The present study aimed to discover osteoclast differentiation inhibitors from the basidiomycete Xylodon flaviporus. Seven new drimane sesquiterpenoids (1-7) and 7-ketoisodrimenin-5-ene (8) were obtained and characterized by various spectroscopic methods. The isolated compounds were evaluated for their inhibitory effects against receptor activator of nuclear factor-kappa-B ligand-induced osteoclastogenesis in mouse… CONTINUE READING
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