Xylitol nasal irrigation in the management of chronic rhinosinusitis: A pilot study

@article{Weissman2011XylitolNI,
  title={Xylitol nasal irrigation in the management of chronic rhinosinusitis: A pilot study},
  author={Joshua D. Weissman and Francisca Fernandez and Peter H. Hwang},
  journal={The Laryngoscope},
  year={2011},
  volume={121}
}
OBJECTIVES/HYPOTHESIS To determine the tolerability of xylitol mixed with water as a nasal irrigant and to evaluate whether xylitol nasal irrigation results in symptomatic improvement of subjects with chronic rhinosinusitis. [...] Key MethodSTUDY DESIGN A prospective, randomized, double-blinded, controlled crossover pilot study. Expand
Results of a RCT assessing saline and xylitol nasal irrigation for CRS and fatigue in Gulf War illness
To assess the efficacy of saline nasal irrigation (S‐NI) and xylitol nasal irrigation (X‐NI) for chronic rhinosinusitis in participants with Gulf War illness (GWI).
Comparison of nasal hyperosmolar xylitol and xylometazoline solutions on quality of life in patients with inferior turbinate hypertrophy secondary to nonallergic rhinitis
The purpose of this study was to objectively determine and compare the efficacy and effectiveness of xylitol solution (Xlear Nasal Sprey®) compared with xylometazoline and physiological saline with
Microbiomics of irrigation with xylitol or Lactococcus lactis in chronic rhinosinusitis
TLDR
Topical sinonasal rinse therapies may alter the local microbiome and improve disease control in chronic rhinosinusitis patients when rinsing with commercially available products containing xylitol or Lactococcus lactis.
The in vitro mucolytic effect of xylitol and dornase alfa on chronic rhinosinusitis mucus
TLDR
There is a clinical need for effective topical mucolytic agents to facilitate removal of mucus and improve postoperative outcomes in chronic rhinosinusitis.
Nasal Irrigation for Chronic Rhinosinusitis and Fatigue in Patients with Gulf War Syndrome
TLDR
The primary activities conducted during year three of the project involved continued coordination with the Madison Veterans Affairs Hospital for subject identification and recruitment, and subject recruitment and enrollment.
Topical therapies in the management of chronic rhinosinusitis: an evidence‐based review with recommendations
TLDR
The purpose of this article is to provide an evidence‐based approach for the utilization of topical therapies in the management of CRS.
Topical Irrigations for Chronic Rhinosinusitis.
  • V. Lee
  • Medicine
    Immunology and allergy clinics of North America
  • 2020
TLDR
As the understanding of the primary cause of chronic rhinosinusitis has shifted away from infection toward inflammation, topical corticosteroid sprays and saline irrigations have become mainstays of treatment and the popularity of topical antibiotics has subsequently waned.
Future topical medications in chronic rhinosinusitis
TLDR
The goal of this review is to summarize and discuss the potential and pitfalls of topical medications in the treatment of CRS.
Xylitol nasal irrigation in the treatment of chronic rhinosinusitis.
TLDR
XNI results in greater improvement of symptoms of CRS and greater enhancement of nasal NO and iNOS mRNA in maxillary sinus as compared to SNI.
Efficacy of nasal irrigations and nebulizations for nasal symptom relief
TLDR
Use of nasal saline irrigations can improve symptoms of sinonasal disease and may improve outcomes in certain settings and the use of xylitol in chronic rhinosinusitis and topical fluconazole in allergic fungal sinusitis appear promising.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 17 REFERENCES
Xylitol Enhances Bacterial Killing in the Rabbit Maxillary Sinus
TLDR
Factors that alter airway surface liquid (ASL) ionic concentrations may influence the course of sinusitis.
Nasal saline for chronic sinonasal symptoms: a randomized controlled trial.
TLDR
Nasal irrigations performed with large volume and delivered with low positive pressure are more effective than saline sprays for treatment of chronic nasal and sinus symptoms in a community-based population.
A novel method to control the balance of skin microflora Part 2. A study to assess the effect of a cream containing farnesol and xylitol on atopic dry skin.
TLDR
Evidence is provided supporting the idea that cream containing F and X is a useful skin-care agent for atopic dry skin colonized by SA.
A novel method to control the balance of skin microflora Part 2. A study to assess the effect of a cream containing farnesol and xylitol on atopic dry skin.
TLDR
Evidence supporting the idea that cream containing F and X is a useful skin-care agent for atopic dry skin colonized by SA is provided.
Antiadhesive effects of xylitol on otopathogenic bacteria.
TLDR
Exposure of epithelial cells or bacteria alone to xylitol did not reduce the adherence of Haemophilus influenzae, although the exposure of both cells and bacteria toxylitol reduced the adherence significantly.
The osmolyte xylitol reduces the salt concentration of airway surface liquid and may enhance bacterial killing.
  • J. Zabner, M. Seiler, +5 authors M. Welsh
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 2000
TLDR
It is found that the five-carbon sugar xylitol has a low transepithelial permeability, is poorly metabolized by several bacteria, and can lower the ASL salt concentration in both CF and non-CF airway epithelia in vitro.
Turku sugar studies XVIII. Incidence of dental caries in relation to 1-year consumption of xylitol chewing gum.
TLDR
The results show a profound difference in the caries increment rate between the two experimental groups, which clearly indicate a therapeutic, caries inhibitory effect of xylitol.
The health impact of chronic sinusitis in patients seeking otolaryngologic care.
  • R. Gliklich, R. Metson
  • Medicine
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • 1995
TLDR
The findings suggest that the national health impact of chronic sinusitis is far greater than is currently appreciated and compared with other chronic diseases.
A novel method to control the balance of skin microflora. Part 1. Attack on biofilm of Staphylococcus aureus without antibiotics.
TLDR
Xylitol and farnesol have potential for controlling the skin-microfloral balance because of their selective effects and inhibition of biofilm formation and might provide a useful and safe method to care for skin colonized by SA, without using antibiotics.
Safety assessment of inhaled xylitol in mice and healthy volunteers
TLDR
Inhalation of aerosolized iso-osmotic xylitol was well-tolerated by naïve and atopic mice, and by healthy human volunteers.
...
1
2
...