Xylitol chewing gum in prevention of acute otitis media: double blind randomised trial

  title={Xylitol chewing gum in prevention of acute otitis media: double blind randomised trial},
  author={Matti Uhari and Tero Kontiokari and Markku Koskela and Marjo Niemela},
  pages={1180 - 1183}
Abstract Objective: To examine whether xylitol, which reduces the growth of Streptococcus pneumoniae, might have clinical importance in the prevention of acute otitis media. Design: A double blind randomised trial with xylitol administered in chewing gum. Setting: Eleven day care nurseries in the city of Oulu. Most of the children had had problems with recurrent acute otitis media. Subjects: 306 day care children: 149 children in the sucrose group (76 boys; mean (SD) age 4.9 (1.5) years) and… 

A Novel Use of Xylitol Sugar in Preventing Acute Otitis Media

Xylitol sugar, when given in a syrup or chewing gum, was effective in preventing AOM and decreasing the need for antimicrobials.

Xylitol Syrup for the Prevention of Acute Otitis Media

Viscous xylitol solution in a dose of 5 g 3 times per day was ineffective in reducing clinically diagnosed AOM among otitis-prone children.

Xylitol administered only during respiratory infections failed to prevent acute otitis media.

Xylitol administered only during an ARI was ineffective in preventing AOM, and parents began administering the products to their children at the onset of symptoms of ARI.

Failure of Xylitol Given Three Times a Day for Preventing Acute Otitis Media

Xylitol given regularly 3 times a day for 3 months during the respiratory infection season failed to prevent AOM.

Xylitol Containing Chewing Gums in the Management of Chronic Otitis Media with Effusion

In the treatment of chronic otitis media with effusion, the chewing gums containing xylitol have been more effective than sorbitol containing gums.

Xylitol for the prevention of acute otitis media episodes in children aged 2–4 years: protocol for a pragmatic randomised controlled trial

Xylitol is a naturally occurring sugar with antibacterial properties that has been used as a natural non-sugar sweetener in chewing gums, confectionery, toothpaste and medicines and will be tested for the prevention of acute otitis media in young children.

Tolerability of oral xylitol solution in young children: implications for otitis media prophylaxis.

Acute otitis media in young children : randomized controlled trials of antimicrobial treatment, prevention and quality of life

Children with AOM and their parents had a significantly poorer QoL than healthy children, and it improved significantly at 1-year follow-up, but it did not reach the level observed in healthy children.

Xylitol for preventing acute otitis media in children up to 12 years of age.

There is moderate quality evidence showing that the prophylactic administration of xylitol among healthy children attending daycare centres can reduce the occurrence of AOM, but there is inconclusive evidence with regard to the efficacy ofxylitol in preventing AOM among children with respiratory infection, or among otitis-prone children.



Microbiologic and clinical aspects of a trial of once daily cefixime compared with twice daily cefaclor for treatment of acute otitis media in infants and children

  • Medicine
    The Pediatric infectious disease journal
  • 1993
Overall efficacy for treatment of acute otitis media with effusion was not different; however, cefixime appeared more effective for infections caused by beta-lactamase-producing organisms.

The occurrence of acute otitis media in infants. A life-table analysis.

Incidence of acute otitis media up to the age of 1 1/2 years in urban infants.

The object of this prospective cohort investigation of 1,642 infants was to study the incidence of acute otitis media in urban children during the first 18 months of life, and the AOM incidence, particularly as regards recurrent AOM, was rather higher in boys than in girls.

Xylitol and caries: the collaborative WHO oral disease preventive programme in Hungary.

The analysis of the data showed highly significant differences between the X-, F- and C-groups when measuring caries activity as the increment of DMF teeth and tooth surfaces, and also as the increments rate assessing the true caries incidence in a biostatistical sense.

Collaborative WHO xylitol field study in French Polynesia. I. Baseline prevalence and 32-month caries increment.

It is concluded that partial sugar substitution by xylitol is a useful tool in preventing caries and should be considered in addition to fluoridation and oral hygiene measures in public oral health programmes.

Effect of xylitol on growth of nasopharyngeal bacteria in vitro

If xylitol reduces the growth of S. pneumoniae in the nasopharynx, it could also reduce the carriage of this pathogen and thus have clinical significance in the prevention of pneumococcal diseases.

Effect of Xylitol on the Growth and Glycolysis of Acidogenic Oral Bacteria

Xylitol inhibited the growth of all but one of ten strains of S. mutans and failed to inhibit the grow of the lactobacilli, actinomycetes, and other streptococci tested except S. sanguis 10556, which was slightly inhibited.

Effect of xylitol on the growth and metabolism of Streptococcus mutans.

Signs of an adaptation to metabolize other compounds (for example, amino acids or peptides) were obtained and xylitol had no strong effect on the uptake of glucose by the cells which were adapted to tolerate this polyol.