Xylitol chewing gum in prevention of acute otitis media: double blind randomised trial

@article{Uhari1996XylitolCG,
  title={Xylitol chewing gum in prevention of acute otitis media: double blind randomised trial},
  author={Matti Uhari and Tero Kontiokari and Markku Koskela and Marjo Niemela},
  journal={BMJ},
  year={1996},
  volume={313},
  pages={1180 - 1183}
}
Abstract Objective: To examine whether xylitol, which reduces the growth of Streptococcus pneumoniae, might have clinical importance in the prevention of acute otitis media. Design: A double blind randomised trial with xylitol administered in chewing gum. Setting: Eleven day care nurseries in the city of Oulu. Most of the children had had problems with recurrent acute otitis media. Subjects: 306 day care children: 149 children in the sucrose group (76 boys; mean (SD) age 4.9 (1.5) years) and… 
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Highly Influential Citations
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Background Citations
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Methods Citations
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202 Citations

A Novel Use of Xylitol Sugar in Preventing Acute Otitis Media

Xylitol sugar, when given in a syrup or chewing gum, was effective in preventing AOM and decreasing the need for antimicrobials.

Xylitol Syrup for the Prevention of Acute Otitis Media

Viscous xylitol solution in a dose of 5 g 3 times per day was ineffective in reducing clinically diagnosed AOM among otitis-prone children.

Xylitol administered only during respiratory infections failed to prevent acute otitis media.

Xylitol administered only during an ARI was ineffective in preventing AOM, and parents began administering the products to their children at the onset of symptoms of ARI.

Failure of Xylitol Given Three Times a Day for Preventing Acute Otitis Media

Xylitol given regularly 3 times a day for 3 months during the respiratory infection season failed to prevent AOM.

Xylitol Containing Chewing Gums in the Management of Chronic Otitis Media with Effusion

In the treatment of chronic otitis media with effusion, the chewing gums containing xylitol have been more effective than sorbitol containing gums.

Xylitol for the prevention of acute otitis media episodes in children aged 2–4 years: protocol for a pragmatic randomised controlled trial

Xylitol is a naturally occurring sugar with antibacterial properties that has been used as a natural non-sugar sweetener in chewing gums, confectionery, toothpaste and medicines and will be tested for the prevention of acute otitis media in young children.

Tolerability of oral xylitol solution in young children: implications for otitis media prophylaxis.

Acute otitis media in young children : randomized controlled trials of antimicrobial treatment, prevention and quality of life

Children with AOM and their parents had a significantly poorer QoL than healthy children, and it improved significantly at 1-year follow-up, but it did not reach the level observed in healthy children.

Treatment of acute otitis media with an antiadhesive oligosaccharide: a randomised, double-blind, placebo-controlled trial

Xylitol for preventing acute otitis media in children up to 12 years of age.

There is moderate quality evidence showing that the prophylactic administration of xylitol among healthy children attending daycare centres can reduce the occurrence of AOM, but there is inconclusive evidence with regard to the efficacy ofxylitol in preventing AOM among children with respiratory infection, or among otitis-prone children.
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