Xylan utilization in human gut commensal bacteria is orchestrated by unique modular organization of polysaccharide-degrading enzymes.

@article{Zhang2014XylanUI,
  title={Xylan utilization in human gut commensal bacteria is orchestrated by unique modular organization of polysaccharide-degrading enzymes.},
  author={Meiling Zhang and Jonathan R Chekan and Dylan Dodd and Pei-Ying Hong and Lauren Radlinski and Vanessa Revindran and Satish K Nair and R. I. Mackie and Isaac K. O. Cann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 35},
  pages={
          E3708-17
        }
}
Enzymes that degrade dietary and host-derived glycans represent the most abundant functional activities encoded by genes unique to the human gut microbiome. However, the biochemical activities of a vast majority of the glycan-degrading enzymes are poorly understood. Here, we use transcriptome sequencing to understand the diversity of genes expressed by the human gut bacteria Bacteroides intestinalis and Bacteroides ovatus grown in monoculture with the abundant dietary polysaccharide xylan. The… CONTINUE READING

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