Xylamine, an irreversible inhibitor of norepinephrine uptake, is transported by this same uptake mechanism in cultured rat superior cervical ganglia.

@article{Fischer1983XylamineAI,
  title={Xylamine, an irreversible inhibitor of norepinephrine uptake, is transported by this same uptake mechanism in cultured rat superior cervical ganglia.},
  author={James B Fischer and L A Waggaman and Richard W Ransom and Arthur K. Cho},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1983},
  volume={226 3},
  pages={650-5}
}
The accumulation of tritium-labeled xylamine ([3H]XYL), an irreversible inhibitor of neuronal norepinephrine (NE) uptake, was studied in organ-cultured rat superior cervical ganglia (SCG). At concentrations below those which significantly inhibit NE uptake, [3H]XYL accumulation was linear with time for up to 2 hr; at higher concentrations, accumulation slowed within the first 10 min. [3H]XYL accumulation was inhibited by desipramine, cocaine, bretylium and by NE at concentrations similar to… CONTINUE READING