Xpd/Ercc2 regulates CAK activity and mitotic progression

@article{Chen2003XpdErcc2RC,
  title={Xpd/Ercc2 regulates CAK activity and mitotic progression},
  author={Jian Chen and St{\'e}phane Larochelle and Xiaoming Li and Beat Suter},
  journal={Nature},
  year={2003},
  volume={424},
  pages={228-232}
}
General transcription factor IIH (TFIIH) consists of nine subunits: cyclin-dependent kinase 7 (Cdk7), cyclin H and MAT1 (forming the Cdk-activating-kinase or CAK complex), the two helicases Xpb/Hay and Xpd, and p34, p44, p52 and p62 (refs 1–3). As the kinase subunit of TFIIH, Cdk7 participates in basal transcription by phosphorylating the carboxy-terminal domain of the largest subunit of RNA polymerase II1,4,5. As part of CAK, Cdk7 also phosphorylates other Cdks, an essential step for their… CONTINUE READING

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