Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing

  title={Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing},
  author={Chun-Kan Chen and Mario Blanco and Constanza Jackson and Erik Aznauryan and Noah Ollikainen and Christine F. Surka and Amy Chow and Andrea Cerase and Patrick McDonel and Mitchell Guttman},
The Xist long noncoding RNA orchestrates X chromosome inactivation, a process that entails chromosome-wide silencing and remodeling of the three-dimensional (3D) structure of the X chromosome. Yet, it remains unclear whether these changes in nuclear structure are mediated by Xist and whether they are required for silencing. Here, we show that Xist directly interacts with the Lamin B receptor, an integral component of the nuclear lamina, and that this interaction is required for Xist-mediated… CONTINUE READING
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