Xist-dependent imprinted X inactivation and the early developmental consequences of its failure

@article{Borensztein2017XistdependentIX,
  title={Xist-dependent imprinted X inactivation and the early developmental consequences of its failure},
  author={Maud Borensztein and Laur{\`e}ne Syx and Katia Ancelin and Patricia Diabangouaya and Christel Picard and Tao Liu and Jun-Bin Liang and Ivaylo Vassilev and Rafael Galupa and Nicolas Servant and Emmanuel Barillot and Azim Surani and Chong-Jian Chen and Edith Heard},
  journal={Nature Structural &Molecular Biology},
  year={2017},
  volume={24},
  pages={226-233}
}
The long noncoding RNA Xist is expressed from only the paternal X chromosome in mouse preimplantation female embryos and mediates transcriptional silencing of that chromosome. In females, absence of Xist leads to postimplantation lethality. Here, through single-cell RNA sequencing of early preimplantation mouse embryos, we found that the initiation of imprinted X-chromosome inactivation absolutely requires Xist. Lack of paternal Xist leads to genome-wide transcriptional misregulation in the… CONTINUE READING