Xid immunodeficiency imparts increased parasite clearance and resistance to pathology in experimental Chagas' disease.

@article{Minoprio1991XidII,
  title={Xid immunodeficiency imparts increased parasite clearance and resistance to pathology in experimental Chagas' disease.},
  author={Paola Marcella Camargo Minoprio and Ant{\'o}nio Coutinho and Sarah Spinella and M Hontebeyrie-Joskowicz},
  journal={International immunology},
  year={1991},
  volume={3 5},
  pages={427-33}
}
Infection of several mouse strains with Trypanosoma cruzi stimulates high levels of T and B lymphocyte activities which persist during the chronic phase and is followed by specific immunosuppression and severe autoimmune pathology. Infected BALB.Xid mice carrying an X-linked mutation and lacking CD5 B cells, display poor B cell responses to T. cruzi infection, accompanied by low levels of specific and non-specific immunoglobulins in the serum. However, these animals control parasitemia, do not… CONTINUE READING

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