Xeroderma pigmentosum variants have decreased repair of ultraviolet-damaged DNA

Abstract

XERODERMA pigmentosum (XP) is an inherited human disease characterised by the development of pigmentation abnormalities and numerous malignancies on sun-exposed areas1. Fibroblasts from typical patients with XP are defective in the repair of ultraviolet-produced damage of their DNA: These cells show (with respect to normal fibroblasts) decreased amounts of… (More)
DOI: 10.1038/253748a0

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