Xeroderma pigmentosum variant heterozygotes show reduced levels of recovery of replicative DNA synthesis in the presence of caffeine after ultraviolet irradiation.

@article{Itoh2000XerodermaPV,
  title={Xeroderma pigmentosum variant heterozygotes show reduced levels of recovery of replicative DNA synthesis in the presence of caffeine after ultraviolet irradiation.},
  author={Toshiki Itoh and S. Linn and Ryoichi Kamide and Hideki Tokushige and Noriko Katori and Yuko Hosaka and Masaru Yamaizumi},
  journal={The Journal of investigative dermatology},
  year={2000},
  volume={115 6},
  pages={981-5}
}
Patients with xeroderma pigmentosum variant show clinical photosensitivity, skin neoplasias induced by ultraviolet light, and defective postreplication repair, but normal nucleotide excision repair. We recently reported an alternative, simple method for the diagnosis of xeroderma pigmentosum variant that measures by autoradiography three cellular markers for DNA repair after ultraviolet irradiation: unscheduled DNA synthesis, recovery of RNA synthesis, and recovery of replicative DNA synthesis… CONTINUE READING

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