Xeroderma pigmentosum complementation group G associated with Cockayne syndrome.

@article{Vermeulen1993XerodermaPC,
  title={Xeroderma pigmentosum complementation group G associated with Cockayne syndrome.},
  author={Wim Vermeulen and Jaak Jaeken and Nicolaas G. J. Jaspers and Dirk Bootsma and Jan H. J. Hoeijmakers},
  journal={American journal of human genetics},
  year={1993},
  volume={53 1},
  pages={185-92}
}
Xeroderma pigmentosum (XP) and Cockayne syndrome (CS) are two rare inherited disorders with a clinical and cellular hypersensitivity to the UV component of the sunlight spectrum. Although the two traits are generally considered as clinically and genetically distinct entities, on the biochemical level a defect in the nucleotide excision-repair (NER) pathway is involved in both. Classical CS patients are primarily deficient in the preferential repair of DNA damage in actively transcribed genes… CONTINUE READING