Xenotransplantation of cryopreserved human ovarian tissue into murine back muscle.

@article{Soleimani2010XenotransplantationOC,
  title={Xenotransplantation of cryopreserved human ovarian tissue into murine back muscle.},
  author={Reza Soleimani and Elke Heytens and Rudy Van den Broecke and Isabelle Rottiers and Marc A Dhont and Claude A. Cuvelier and Petra de Sutter},
  journal={Human reproduction},
  year={2010},
  volume={25 6},
  pages={1458-70}
}
BACKGROUND Ovarian tissue (OT) cryopreservation and transplantation are options for fertility preservation in young female cancer patients. METHODS We investigated xenotransplantation of human OT into back muscle (B) of severe combined immunodeficiency mice. OT follicle content was evaluated by stereomicroscopy and pre-transplantation. Xenograft survival, follicular development (with/without FSH administration), apoptosis and vascularization were compared in B- versus K-site (under the kidney… CONTINUE READING