Xenotransplantation-current status and future perspectives.

  title={Xenotransplantation-current status and future perspectives.},
  author={Emanuele Cozzi and Erika Bosio and Michela Seveso and Marta Vadori and Ermanno Ancona},
  journal={British medical bulletin},
Research efforts have shed light on the immunological obstacles to long-term survival of pig organs transplanted into primates and allowed the identification of targets for specific immune intervention. Accordingly, the development of genetically engineered animals has overcome the hyperacute rejection barrier, with acute humoral xenograft rejection (AHXR) currently remaining the most important immunological obstacle. At this stage, a better control of the elicited anti-pig humoral immune… CONTINUE READING
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Human organ and tissue

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