Xenotransplantation: a tool for reproductive biology and animal conservation?

@article{Paris2004XenotransplantationAT,
  title={Xenotransplantation: a tool for reproductive biology and animal conservation?},
  author={M. Paris and M. Snow and S. Cox and J. Shaw},
  journal={Theriogenology},
  year={2004},
  volume={61 2-3},
  pages={
          277-91
        }
}
The transplantation of reproductive organs, including ovaries and ovarian tissue, was pioneered over 100 years ago. In the 1960s, ovarian grafting was used as a tool to investigate ovarian function, but with the recent development of more effective cryopreservation protocols for ovarian tissue, germline preservation and propagation have now become realistic goals. This review describes progress in ovarian banking and ovarian tissue transplantation, with emphasis on how fresh and frozen ovarian… Expand
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TLDR
The various current and emerging preservation technologies are reviewed, and their advantages and limitations are discussed. Expand
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TLDR
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TLDR
A review of past and current research in the field of oocyte and ovarian tissue cryopreservation and transplantation and discussion of possible strategies for oocytes and ovarian tissue banking are provided. Expand
Cryopreservation and orthotopic transplantation of mouse ovaries: new approach in gamete banking.
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These experiments demonstrate that ovary cryopreservation can be a very useful option for banking mouse germplasm, or managing subfertile animal colonies, when embryo or sperm freezing cannot be used or is not cost effective. Expand
Gonadotrophin administration can benefit ovarian tissue grafted to the body wall: implications for human ovarian grafting
TLDR
It was shown that exogenous gonadotrophins, given to either the donor or the recipient, could increase the number of developing follicles but the magnitude of this effect was influenced by the timing of the injections relative to the time of grafting. Expand
Early massive follicle loss and apoptosis in heterotopically grafted newborn mouse ovaries.
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The results of the present study indicate that transplantation rather than cryopreservation accounts for the major and early loss of primordial follicles in grafted newborn mouse ovaries. Expand
Transplantation of cryopreserved human ovarian tissue results in follicle growth initiation in SCID mice.
TLDR
Human primordial follicles survive freeze-thaw and long-term xenografting procedures and retain their capacity to initiate growth, and encourage future attempts for human autologous ovarian transplantation. Expand
Antral follicles develop in xenografted cryopreserved African elephant (Loxodonta africana) ovarian tissue.
TLDR
The nude mouse model is effective for assessing cryopreserved ovarian tissue xenograft function which can support the development of antral follicles in ovariectomized mice, although oocytes were of poor morphological appearance or only cumulus-like complexes were seen. Expand
Fresh and cryopreserved ovarian tissue samples from donors with lymphoma transmit the cancer to graft recipients.
TLDR
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The success of ovarian transplants in these non-human primates with menstrual cycles bodes well for the development of ovarian transplantation protocols for women at risk of ovarian failure. Expand
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The successful transplantation of frozen, banked autologous ovarian tissue according to a protocol approved by the institutional review board at the center is reported. Expand
Xenotransplantation: The Transplantation of Organs and Tissues Between Species
TLDR
The work described in this book traces the development of the science of cross-spe cies transplantation, summarizes the current state of knowledge, and focuses on approaches directed toward future clinical application. Expand
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