Xenopus skip modulates Wnt/beta-catenin signaling and functions in neural crest induction.

Abstract

The beta-catenin-lymphoid enhancer factor (LEF) protein complex is the key mediator of canonical Wnt signaling and initiates target gene transcription upon ligand stimulation. In addition to beta-catenin and LEF themselves, many other proteins have been identified as necessary cofactors. Here we report that the evolutionally conserved splicing factor and… (More)
DOI: 10.1074/jbc.M109.058347

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