Xenopus msx-1 regulates dorso-ventral axis formation by suppressing the expression of organizer genes.

@article{Takeda2000XenopusMR,
  title={Xenopus msx-1 regulates dorso-ventral axis formation by suppressing the expression of organizer genes.},
  author={Masatoshi Takeda and Yuichirou Saito and Rieko Sekine and Ichiro Onitsuka and Ryu Maeda and Mitsugu Ma{\'e}no},
  journal={Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology},
  year={2000},
  volume={126 2},
  pages={157-68}
}
We demonstrated previously that Xmsx-1 is involved in mesoderm patterning along the dorso-ventral axis, under the regulation of BMP-4 signaling. When Xmsx-1 RNA was injected into the dorsal blastomeres, a mass of muscle tissue formed instead of notochord. This activity was similar to that of Xwnt-8 reported previously. In this study, we investigated whether the activity of Xmsx-1 is related to the ventralizing signal and myogenesis promoting factor, Xwnt-8. Whole-mount in situ hybridization… CONTINUE READING

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