Xenopus laevis as a model for studying thyroid hormone signalling: from development to metamorphosis.

@article{MorvanDubois2008XenopusLA,
  title={Xenopus laevis as a model for studying thyroid hormone signalling: from development to metamorphosis.},
  author={Ghislaine Morvan-Dubois and Barbara A Demeneix and Laurent M. Sachs},
  journal={Molecular and cellular endocrinology},
  year={2008},
  volume={293 1-2},
  pages={71-9}
}
Amphibian metamorphosis is a well-established model for dissecting the mechanisms underlying thyroid hormone (TH) action. How the pro-hormone, T(4), the active form, T(3), the deiodinases and the nuclear receptors (TRs) contribute to metamorphosis in Xenopus has been extensively investigated. Our recent work has concentrated on two key ideas in TH signalling in Xenopus: first, that there could be active roles for both liganded and unliganded receptors, and second, that ligand availability is a… CONTINUE READING
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