Xenopus

@article{Wallingford2010Xenopus,
  title={Xenopus},
  author={John B. Wallingford and Karen J. Liu and Yixian Zheng},
  journal={Current Biology},
  year={2010},
  volume={20},
  pages={R263-R264}
}
  • J. Wallingford, Karen J. Liu, Yixian Zheng
  • Published 2010
  • Medicine
  • Current Biology
Who or what is Xenopus? Xenopus (literally ‘strange foot’) is a genus of aquatic frogs that are native to southern Africa. These frogs are remarkably tolerant to starvation, disease, and other insults, allowing the genus to span more than 45 degrees of latitude in Sub-Saharan Africa. This formidable constitution also makes them very easy to keep in captivity, and thus Xenopus frogs are very widely used as model organisms for biomedical research (Figure 1). Each Xenopus female lays thousands of… Expand
Xenopus as a platform for discovery of genes relevant to human disease.
TLDR
This review provides numerous examples describing the successful use of Xenopus to investigate the contribution of patient mutations to complex phenotypes including congenital heart disease and heterotaxy and describes a variety of unique methods that allow us to rapidly recapitulate patients' phenotypes in frogs. Expand
Breeding Based Remobilization of Tol2 Transposon in Xenopus tropicalis
TLDR
It is shown that the Tol2 transposon can be remobilized in the genome of X. tropicalis and passed through the germline via a simple breeding strategy of crossing transposase expressing and transpos on lines. Expand
GDF 3 , a BMP inhibitor , regulates cell fate in stem cells and early embryos
INTRODUCTION To begin to understand the molecular character of totipotent cells and the mechanisms of the primary cell fate decisions of the early mammalian embryo, we previously performed a globalExpand
Protein localization screening in vivo reveals novel regulators of multiciliated cell development and function
TLDR
The subcellular localization in MCCs of ∼200 proteins not previously implicated in cilia biology are defined, and functional analyses arising from the screen provide novel links between actin cytoskeleton and MCC ciliogenesis. Expand
High-content protein localization screening in vivo reveals novel regulators of multiciliated cell development and function
TLDR
Functional analyses that arose from results of the screen provide novel insights into the mechanisms by which the actin cytoskeleton simultaneously influences diverse aspects of MCC biology, including basal body docking, and ciliogenesis. Expand
Toward the understanding of biology of oocyte life cycle in Xenopus Laevis: No oocytes left behind
TLDR
This work focuses on the developmental and reproductive biology of the female gametes, oocytes, and eggs, of the African clawed frog Xenopus laevis. Expand
Developmental changes in head movement kinematics during swimming in Xenopus laevis tadpoles
TLDR
Examination of head movements and swimming kinematics of Xenopus laevis tadpoles with a body length of 10–45 mm and comparison with fictive swimming revealed very similar swimming frequencies for similarly sized animals, including a comparable developmental decrease of the swimming frequency. Expand
Egg-in-Cube: Design and Fabrication of a Novel Artificial Eggshell with Functionalized Surface
TLDR
A novel artificial eggshell with functionalized surface is proposed, which allows the total amount of oxygen to pass into the egg for the chick embryo culturing and has high observability and accessibility for embryo manipulation. Expand
Quantifying Demyelination in NK venom treated nerve using its electric circuit model
Reduction of myelin in peripheral nerve causes critical demyelinating diseases such as chronic inflammatory demyelinating polyneuropathy, Guillain-Barre syndrome, etc. Clinical monitoring of theseExpand
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