Xenopus TACC3/maskin is not required for microtubule stability but is required for anchoring microtubules at the centrosome.

@article{Albee2008XenopusTI,
  title={Xenopus TACC3/maskin is not required for microtubule stability but is required for anchoring microtubules at the centrosome.},
  author={Alison J. Albee and Christiane Wiese},
  journal={Molecular biology of the cell},
  year={2008},
  volume={19 8},
  pages={
          3347-56
        }
}
Members of the transforming acidic coiled coil (TACC) protein family are emerging as important mitotic spindle assembly proteins in a variety of organisms. The molecular details of how TACC proteins function are unknown, but TACC proteins have been proposed to recruit microtubule-stabilizing proteins of the tumor overexpressed gene (TOG) family to the centrosome and to facilitate their loading onto newly emerging microtubules. Using Xenopus egg extracts and in vitro assays, we show that the… CONTINUE READING
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