Xenopus Nanos1 is required to prevent endoderm gene expression and apoptosis in primordial germ cells.

@article{Lai2012XenopusNI,
  title={Xenopus Nanos1 is required to prevent endoderm gene expression and apoptosis in primordial germ cells.},
  author={Fangfang Lai and A Mahendra Singh and Mary Lou King},
  journal={Development},
  year={2012},
  volume={139 8},
  pages={
          1476-86
        }
}
Nanos is expressed in multipotent cells, stem cells and primordial germ cells (PGCs) of organisms as diverse as jellyfish and humans. It functions together with Pumilio to translationally repress targeted mRNAs. Here we show by loss-of-function experiments that Xenopus Nanos1 is required to preserve PGC fate. Morpholino knockdown of maternal Nanos1 resulted in a striking decrease in PGCs and a loss of germ cells from the gonads. Lineage tracing and TUNEL staining reveal that Nanos1-deficient… CONTINUE READING

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