Xenopus Drf1, a regulator of Cdc7, displays checkpoint-dependent accumulation on chromatin during an S-phase arrest.

@article{Yanow2003XenopusDA,
  title={Xenopus Drf1, a regulator of Cdc7, displays checkpoint-dependent accumulation on chromatin during an S-phase arrest.},
  author={Stephanie K. Yanow and Daniel A. Gold and Hae Yong Yoo and William G. Dunphy},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 42},
  pages={41083-92}
}
We have cloned a Xenopus Dbf4-related factor named Drf1 and characterized this protein by using Xenopus egg extracts. Drf1 forms an active complex with the kinase Cdc7. However, most of the Cdc7 in egg extracts is not associated with Drf1, which raises the possibility that some or all of the remaining Cdc7 is bound to another Dbf4-related protein. Immunodepletion of Drf1 does not prevent DNA replication in egg extracts. Consistent with this observation, Cdc45 can still associate with chromatin… CONTINUE READING
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