Xenopus Cut5 is essential for a CDK-dependent process in the initiation of DNA replication.

@article{Hashimoto2003XenopusCI,
  title={Xenopus Cut5 is essential for a CDK-dependent process in the initiation of DNA replication.},
  author={Yoshitami Hashimoto and Haruhiko Takisawa},
  journal={The EMBO journal},
  year={2003},
  volume={22 10},
  pages={2526-35}
}
Fission yeast Cut5/Rad4 and its budding yeast homolog Dpb11 are required for both DNA replication and the S-phase checkpoint. Here, we have investigated the role of the Xenopus homolog of Cut5 in the initiation of DNA replication using Xenopus egg extracts. Xenopus Cut5, which shows sequence similarity to DmMus101 and HsTopBP1, is essential for DNA replication in the egg extracts. It is required for the chromatin binding of Cdc45 and DNA polymerases, but not for the formation of pre-replicative… CONTINUE READING
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