Xenopus Cep57 Is a Novel Kinetochore Component Involved in Microtubule Attachment

@article{Emanuele2007XenopusCI,
  title={Xenopus Cep57 Is a Novel Kinetochore Component Involved in Microtubule Attachment},
  author={Michael J. Emanuele and P. Stukenberg},
  journal={Cell},
  year={2007},
  volume={130},
  pages={893-905}
}
For chromosomes to congress and segregate during cell division, kinetochores must form stable attachments with spindle microtubules. We find that the centrosome protein, xCep57, localizes to kinetochores and interacts with the kinetochore proteins Zwint, Mis12, and CLIP-170. Immunodepletion of xCep57 from egg extracts yields weakened and elongated bipolar spindles which fail to align chromosomes. In the absence of xCep57, tension is lost between sister kinetochores, and spindle microtubules are… Expand
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