Xenopus CAF1 requires NOT1-mediated interaction with 4E-T to repress translation in vivo.

@article{Waghray2015XenopusCR,
  title={Xenopus CAF1 requires NOT1-mediated interaction with 4E-T to repress translation in vivo.},
  author={Shruti Waghray and Clay E. Williams and Joshua J. Coon and Marvin P. Wickens},
  journal={RNA},
  year={2015},
  volume={21 7},
  pages={1335-45}
}
RNA-regulatory factors bound to 3' UTRs control translation and stability. Repression often is associated with poly(A) removal. The deadenylase CAF1 is a core component of the CCR4-NOT complex. Our prior studies established that CAF1 represses translation independent of deadenylation. We sought the mechanism of its deadenylation-independent repression in Xenopus oocytes. Our data reveal a chain of interacting proteins that links CAF1 to CCR4-NOT and to Xp54 and 4E-T. Association of CAF1 with… CONTINUE READING