Xenopus, an ideal model system to study vertebrate left-right asymmetry.

  title={Xenopus, an ideal model system to study vertebrate left-right asymmetry.},
  author={Martin Blum and Tina Beyer and Thomas A. Weber and Philipp Vick and Philipp Andr{\'e} and Eva Bitzer and Axel Schweickert},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  volume={238 6},
Vertebrate organ laterality is manifested by the asymmetric morphogenesis and placement of inner organs. Asymmetric induction of the Nodal signaling cascade in the left lateral plate mesoderm (LPM) precedes and is essential for asymmetric organ morphogenesis. While the Nodal cascade is highly conserved, symmetry breakage is considered to vary between the different classes of the vertebrates. In Xenopus, early determinants at cleavage stages were thought to break symmetry, opposed to cilia… CONTINUE READING
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