Xenopsin-related peptide(s) are formed from xenopsin precursor by leukocyte protease(s) and cathepsin D

@article{Carraway1991XenopsinrelatedPA,
  title={Xenopsin-related peptide(s) are formed from xenopsin precursor by leukocyte protease(s) and cathepsin D},
  author={R. Carraway and S. P. Mitra and K. Muraki},
  journal={Peptides},
  year={1991},
  volume={12},
  pages={107-112}
}
Lysates of isolated rat polymorphonuclear leukocytes and macrophages were found to generate xenopsin-related peptides when incubated with a liver extract used as a source of precursor. The lysosomal enzyme, cathepsin D, was also shown to display this property and to share with the lysate a similar pH dependence (optimum, approximately pH 3.5) and sensitivity to the acid protease inhibitor, pepstatin A (ID50: lysate, 10 nM; cathepsin D, 30 nM). When subjected to HPLC on mu-Bondapak C-18, the… Expand
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