Xenopsin-related peptide(s) are formed from xenopsin precursor by leukocyte protease(s) and cathepsin D
@article{Carraway1991XenopsinrelatedPA, title={Xenopsin-related peptide(s) are formed from xenopsin precursor by leukocyte protease(s) and cathepsin D}, author={R. Carraway and S. P. Mitra and K. Muraki}, journal={Peptides}, year={1991}, volume={12}, pages={107-112} }
Lysates of isolated rat polymorphonuclear leukocytes and macrophages were found to generate xenopsin-related peptides when incubated with a liver extract used as a source of precursor. The lysosomal enzyme, cathepsin D, was also shown to display this property and to share with the lysate a similar pH dependence (optimum, approximately pH 3.5) and sensitivity to the acid protease inhibitor, pepstatin A (ID50: lysate, 10 nM; cathepsin D, 30 nM). When subjected to HPLC on mu-Bondapak C-18, the… Expand
Topics from this paper
10 Citations
Generation of xenopsin-related peptides from tissue precursors by media conditioned by endotoxin-stimulated rat peritoneal macrophages
- Biology, Medicine
- Inflammation
- 2004
- 2
Pro-xenopsin(s) in vesicles of mammalian brain, liver, stomach and intestine is apparently released into blood and cerebral spinal fluid
- Biology, Medicine
- Regulatory Peptides
- 2000
- 1
Hemorphin Peptides are Released from Hemoglobin by Cathepsin D. Radioimmunoassay Against the C-part of V-V-hemorphin-7: An Alternative Assay for the Cathepsin D Activity
- Chemistry, Medicine
- Peptides
- 1997
- 23
Purification and characterization of enkephalin-related peptides released by in vitro peptic digestion of bovine plasma proteins
- Chemistry, Medicine
- Peptides
- 1994
- 8
Generation of VV‐hemorphin‐7 from globin by peritoneal macrophages
- Biology, Medicine
- FEBS letters
- 1996
- 36
Adsorption of (Phe-h5)/(Phe-d5)-substituted peptides from neurotensin family on the nanostructured surfaces of Ag and Cu: SERS studies.
- Medicine, Chemistry
- Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
- 2020
Neokyotorphin Formation and Quantitative Evolution following Human Hemoglobin Hydrolysis with Cathepsin D
- Chemistry, Medicine
- Peptides
- 1998
- 7
Histamine releasing peptide (HRP) has proinflammatory effects and is present at sites of inflammation.
- Biology, Medicine
- Biochemical pharmacology
- 2003
- 5
Elevated circulating levels of xenopsin-related peptide-1 are associated with polycystic ovary syndrome
- Medicine
- Archives of Gynecology and Obstetrics
- 2017
- 1
References
SHOWING 1-10 OF 14 REFERENCES
Generation of xenopsin-related peptides during acid extraction of gastric tissues.
- Medicine, Biology
- The Journal of biological chemistry
- 1985
- 24
Isolation and structures of xenopsin-related peptides from rat stomach, liver and brain
- Biology, Medicine
- Regulatory Peptides
- 1990
- 17
Xenopsin-related peptide generated in avian gastric extracts
- Biology, Medicine
- Regulatory Peptides
- 1988
- 18
Isolation and sequence of canine xenopsin and an extended fragment from its precursor
- Biology, Medicine
- Peptides
- 1990
- 8
Evidence for the presence of xenopsin-related peptide(s) in the gastric mucosa of mammals.
- Medicine, Biology
- The Journal of clinical investigation
- 1985
- 26
- PDF
Isolation and structure of a new active peptide xenopsin on rat stomach strip and some biogenic amines in the skin of Xenopus laevis.
- Chemistry, Medicine
- Chemical & pharmaceutical bulletin
- 1975
- 45
Amphibian neurotensin (NT) is not xenopsin (XP): dual presence of NT-like and XP-like peptides in various amphibia.
- Biology, Medicine
- Endocrinology
- 1982
- 41
Canine neurotensin, neurotensin6–13 and neuromedin N: primary structures and receptor activity
- Biology, Medicine
- Regulatory Peptides
- 1990
- 16
Exocrine secretion and processing of pro-xenopsin in rat gastric lumen.
- Chemistry, Medicine
- The American journal of physiology
- 1990
- 5