Xenon preconditioning confers neuroprotection regardless of gender in a mouse model of transient middle cerebral artery occlusion.

@article{Limatola2010XenonPC,
  title={Xenon preconditioning confers neuroprotection regardless of gender in a mouse model of transient middle cerebral artery occlusion.},
  author={Vittorio Limatola and Phil N Ward and Davide Cattano and J Gu and Francesco Giunta and Mervyn M Maze and Daqing Ma},
  journal={Neuroscience},
  year={2010},
  volume={165 3},
  pages={874-81}
}
Xenon preconditioning induces tolerance to the consequences of an injurious stimulus such as cerebral ischaemia. There have been surprisingly few studies investigating gender difference in the efficacy of pharmacological preconditioning, despite the known ability of oestradiol to exert neuroprotectant activity. We explored this paradigm using a mouse model of transient middle cerebral artery occlusion. C57BL/6 mice both male and female received either 2 h of 70% xenon (preconditioning) or 70… CONTINUE READING

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