Xenon is an Inhibitor of Tissue-Plasminogen Activator: Adverse and Beneficial Effects in a Rat Model of Thromboembolic Stroke

@article{David2010XenonIA,
  title={Xenon is an Inhibitor of Tissue-Plasminogen Activator: Adverse and Beneficial Effects in a Rat Model of Thromboembolic Stroke},
  author={H{\'e}l{\`e}ne N. David and Benoit Haelewyn and Jean-Jacques Risso and Nathalie Colloc'h and Jacques H Abraini},
  journal={Journal of Cerebral Blood Flow & Metabolism},
  year={2010},
  volume={30},
  pages={718 - 728}
}
Preclinical evidence in rodents has proven that xenon may be a very promising neuroprotective agent for treating acute ischemic stroke. This has led to the general thinking that clinical trials with xenon could be initiated in acute stroke patients in a next future. However, an unappreciated physicochemical property of xenon has been that this gas also binds to the active site of a series of serine proteases. Because the active site of serine proteases is structurally conserved, we have… CONTINUE READING

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