Xenon inhibits but N(2)O enhances ketamine-induced c-Fos expression in the rat posterior cingulate and retrosplenial cortices.

@article{Nagata2001XenonIB,
  title={Xenon inhibits but N(2)O enhances ketamine-induced c-Fos expression in the rat posterior cingulate and retrosplenial cortices.},
  author={Atsushi Nagata and S Nakao Si and Nobuyasu Nishizawa and Munehiro Masuzawa and Takefumi Inada and Kouhei Murao and Etsuko Miyamoto and Koh Shingu},
  journal={Anesthesia and analgesia},
  year={2001},
  volume={92 2},
  pages={
          362-8
        }
}
  • Atsushi Nagata, S Nakao Si, +5 authors Koh Shingu
  • Published 2001
  • Medicine
  • Anesthesia and analgesia
  • Both nitrous oxide (N(2)O) and xenon are N:-methyl-D-aspartate receptor antagonists that have psychotomimetic effects and cause neuronal injuries in the posterior cingulate and retrosplenial cortices. We investigated the effect of xenon, xenon with ketamine, N(2)O, and N(2)O with ketamine on c-Fos expression in the rat posterior cingulate and retrosplenial cortices, a marker of psychotomimetic effects. Brain sections were prepared, and c-Fos expression was detected with immunohistochemical… CONTINUE READING

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