Xenon attenuates hippocampal long-term potentiation by diminishing synaptic and extrasynaptic N-methyl-D-aspartate receptor currents.

@article{Kratzer2012XenonAH,
  title={Xenon attenuates hippocampal long-term potentiation by diminishing synaptic and extrasynaptic N-methyl-D-aspartate receptor currents.},
  author={Stephan Kratzer and Corinna Mattusch and Eberhard F. Kochs and Matthias Eder and Rainer Haseneder and Gerhard Rammes},
  journal={Anesthesiology},
  year={2012},
  volume={116 3},
  pages={
          673-82
        }
}
BACKGROUND The memory-blocking properties of general anesthetics are of high clinical relevance and scientific interest. The inhalational anesthetic xenon antagonizes N-methyl-D-aspartate (NMDA) receptors. It is unknown if xenon affects long-term potentiation (LTP), a cellular correlate for memory formation. In hippocampal brain slices, the authors investigated in area CA1 whether xenon affects LTP, NMDA receptor-mediated neurotransmission, and intracellular calcium concentrations. METHODS In… CONTINUE READING

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