Xenon attenuates cardiopulmonary bypass-induced neurologic and neurocognitive dysfunction in the rat.

@article{Ma2003XenonAC,
  title={Xenon attenuates cardiopulmonary bypass-induced neurologic and neurocognitive dysfunction in the rat.},
  author={Daqing Ma and Hong Yang and John Lynch and Nicholas P Franks and Mervyn M Maze and Hilary P. Grocott},
  journal={Anesthesiology},
  year={2003},
  volume={98 3},
  pages={690-8}
}
BACKGROUND With clinical data suggesting a role for excitatory amino acid neurotransmission in the pathogenesis of cardiopulmonary bypass (CPB)-associated brain injury, the current study was designed to determine whether xenon, an N-methyl-D-aspartate receptor antagonist, would attenuate CPB-induced neurologic and neurocognitive dysfunction in the rat. METHODS Following surgical preparation, rats were randomly divided into four groups: (1) sham rats were cannulated but did not undergo CPB; (2… CONTINUE READING

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