Xenon Misuse in Sports – Increase of Hypoxia-Inducible Factors and Erythropoietin, or Nothing but „Hot Air“?

@article{Jelkmann2014XenonMI,
  title={Xenon Misuse in Sports – Increase of Hypoxia-Inducible Factors and Erythropoietin, or Nothing but „Hot Air“?},
  author={W. Jelkmann},
  journal={Deutsche Zeitschrift Fur Sportmedizin},
  year={2014},
  volume={2014},
  pages={267-271}
}
  • W. Jelkmann
  • Published 2014
  • Medicine, Chemistry
  • Deutsche Zeitschrift Fur Sportmedizin
Experimental evidence suggests that xenon (Xe) is not completely inert but can affect the functional properties of proteins, particularly that of ion channels and of enzymes. According to recent reports xenon can activate the hypoxia-inducible transcription factors (HIF). A number of preclinical investigations (cell culture experiments, animal studies) has been performed concerning this, but the results have been volatile and the mechanism of HIF activation differed from that of hypoxia… Expand
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References

SHOWING 1-10 OF 27 REFERENCES
Regulation of erythropoiesis by hypoxia-inducible factors.
  • V. Haase
  • Biology, Medicine
  • Blood reviews
  • 2013
TLDR
A perspective on recent insights into HIF-controlled erythropoiesis and iron metabolism is provided, and cell types that have EPO-producing capability are examined, and the therapeutic potential of pharmacologic HIF activation for the treatment of anemia is discussed. Expand
The role of hypoxia-inducible factor-1α and vascular endothelial growth factor in late phase preconditioning with xenon, isoflurane and levosimendan in rat cardiac myocytes
TLDR
Xenon-induced preconditioning does not lead to an increase in cyclooxygenase-2 gene transcription but to a significant increase in hypoxia-inducible factor-1α and subsequently vascular endothelial growth factor, and the main finding is that the stimulation of late phase preconditionsing involves several distinct pathways that are variably addressed by the different stimuli. Expand
Hypoxia-inducible factor stabilizers and other small-molecule erythropoiesis-stimulating agents in current and preventive doping analysis.
TLDR
The erythropoiesis-stimulating properties and doping relevance of experimental HIF-stabilizers, such as cobaltous chloride, 3,4-dihydroxybenzoic acid or GSK360A, amongst others, are discussed and exemplary molecular structures of HIF stabilizers presented. Expand
Hypoxia-inducible factor 1 and related gene products in anaesthetic-induced preconditioning
TLDR
A better understanding of the molecular mechanisms that mediate cardioprotection by volatile anaesthetics might help to introduce specific applications of these substances for organ-protective purposes in patients with cardiovascular diseases. Expand
Xenon preconditioning protects against renal ischemic-reperfusion injury via HIF-1alpha activation.
  • D. Ma, T. Lim, +6 authors M. Maze
  • Medicine
  • Journal of the American Society of Nephrology : JASN
  • 2009
TLDR
It is shown that preconditioning with the anesthetic gas xenon activates hypoxia-inducible factor 1alpha and its downstream effectors erythropoietin and vascular endothelial growth factor in a time-dependent manner in the kidneys of adult mice, and that administration of xenon before renal ischemia can prevent acute renal failure. Expand
Prolyl 4‐hydroxylases, master regulators of the hypoxia response
TLDR
Induction of the hypoxia response via inhibition of the HIF prolyl 4‐hydroxylase isoenzymes may provide a novel therapeutic target in the treatment of Hypoxia‐associated diseases. Expand
Intermittent Exposure to Xenon Protects against Gentamicin-Induced Nephrotoxicity
TLDR
Xe renoprotection against gentamicin-induced nephrotoxicity is supported, which was characterized by attenuation of renal tubular damage, apoptosis, and oxidative stress, but not a reduction in inflammation. Expand
Effect of noble gases on oxygen and glucose deprived injury in human tubular kidney cells
TLDR
It is suggested that unlike other noble gases, preconditioning with the anesthetic noble gas xenon may have a role in protection against renal ischemic injury. Expand
Intolerability of cobalt salt as erythropoietic agent.
TLDR
New insights should keep athletes off taking Co(2+) to stimulate erythropoiesis, as the intake of inorganic cobalt can cause severe organ damage, concerning primarily the gastrointestinal tract, the thyroid, the heart and the sensory systems. Expand
Neuroprotective effects of xenon: a therapeutic window of opportunity in rats subjected to transient cerebral ischemia
  • H. N. David, B. Haelewyn, +6 authors J. Abraini
  • Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2008
TLDR
It is shown that xenon, administered at subanesthetic doses, offers global neuroprotection from reduction of neurotransmitter release induced by ischemia, a critical event known to be involved in excitotoxicity, to reduction of subsequent cell injury and neuronal death. Expand
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